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吴晓进教授课题组在Chemical Communications发表研究论文
阅读次数: 添加时间:2021/09/02 发布:

Catalytic base-controlled regiodivergent heteronucleophilic hydrofunctionalization of β,γ-unsaturated amides

Yao Zhao, a Jiacheng Rui, a Qiang Du, a Rizhi Chen, b Ying Zhan, a Xintao Zheng, a Xiaojin Wu*a

aInstitute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, China.

bState Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing 211816, China


Abstract: A general catalytic base-controlled regiodivergent nucleophilic hydrofunctionalization of both terminal and internal β,γ-unsaturated amides has been reported. The atom-economical addition of various S/P-based nucleophiles was also exclusively chemoselective. More than 60 branched or linear heterosubstituted aliphatic amides were synthesized from common starting materials under transition-metal-free conditions. Preliminary mechanistic studies are consistent with our proposed divergent catalytic cycles.

Chem. Commun. DOI: 10.1039/D1CC03440E (IF = 6.222)

文章链接:https://doi.org/10.1039/D1CC03440E

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