张磊，女，1988年出生，分析化学博士，硕士生导师

邮箱：ias_lzhang@njtech.edu.cn

教育经历

2012.09-2015.09，南京大学,化学化工学院,理学博士,导师:鞠熀先,雷建平

2009.09-2012.06, 厦门大学,化学化工学院,理学硕士,导师:李顺华

2005.09-2009.06, 南京师范大学,化学与环境科学学院,理学学士

科研工作经历

2017.06-至今  南京工业大学,化学与分子工程学院，副研究员

2018.12-2021.03  德国慕尼黑大学（LMU），生物物理系，亚历山大・冯・洪堡学者，合作教授 Thorben Cordes

2015.10-2017.05  南京大学，化学化工学院，助理研究员

主持的科研项目

主持国家自然科学基金委面上项目和青年项目，江苏省科技厅青年项目，江苏省双创博士，江苏省高等学校自然科学面上项目

研究方向

方向一：荧光分子探针与生物传感

方向二：单分子光物理性能研究与超分辨荧光成像

代表性论文（仅包括以第一、通讯作者）

(1) Tong Zhou, Shuyan Zhang, Lei Zhang*, Tianyue Jiang, Haiyang Wang, Ling Huang, Hongshuai Wu, Zhining Fan, Su Jing*.Redox ferrocenylseleno compounds modulate longitudinal and transverse relaxation times of FNPs-Gd MRI contrast agents for multimodal imaging and photo-Fenton therapy. Acta Biomaterialia, 2023, 164, 496–510. (IF=10.633).

(2) Lei Zhang, Michael Isselstein, Jens Köhler, Nikoloas Eleftheriadis, Nadia Huisjes, Miguel Guirao, Alessandra Narducci, Jochem Smit, Janko Stoffels, Hartmann Harz, Heinrich Leonhardt, Andreas Herrmann,* Thorben Cordes.* Linker molecules convert commercial fluorophores into tailored functional probes during bio-labeling. Angewandte Chemie International Edition, 2022, 61, e202112959. (Cover paper, VIP and Hot, IF=16.823)

(3) Lei Zhang, Gill M. Biesold, Chunyan Zhao, Hui Xu, Zhiqun Lin, Necklace-like Nanostructures: from Fabrication, Properties to Applications. Advanced Materials, 2022, 34, 2200776. (IF=32.086)

(4) Lei Zhang, Fengjiao Ma, Jianping, Lei,* Jintong Liu, Huangxin Ju.* Target-triggered cascade assembly of catalytic network as artificial enzyme for highly efficient sensing. Chemical Science 2017, 8, 4833–4839. (IF=9.969)

(5) Yuban Ji,^# Lei Zhang,^# Longyi Zhu, Jianping Lei,* Jie Wu, Huangxian Ju. Binding-Induced DNA Walker for Signal Amplification in Highly Selective Electrochemical Detection of Protein. Biosensors & Bioelectronics 2017, 96, 201–205. (^# equal contribution) (IF=12.545)

(6) Lei Zhang, Jianping Lei,* Jintong Liu, Fengjiao Ma, Huangxian Ju.* In Situ Activating and Monitoring the Evolution of Intracellular Caspase Family. Chemical Science 2015, 6, 3365–3372. (IF=9.969)

(7) Lei Zhang, Jianping Lei,* Jintong Liu, Fengjiao Ma, Huangxian Ju.* Persistent Luminescence Nanoprobe for Biosensing and Lifetime Imaging of Cell Apoptosis via Time-Resolved Fluorescence Resonance Energy Transfer. Biomaterials 2015, 67, 323–334. (IF=15.304)

(8) Jintong Liu,^# Lei Zhang,^# Jianping Lei,* Huangxian Ju.* MicroRNA-Responsive Cancer Cell Imaging and Therapy with Functionalized Gold Nanoprobe. ACS Applied Materials & Interfaces 2015, 7, 19016–19023. (^# equal contribution) (IF=10.383)

(9) Xiulian Lu, XuewenWang, Aimin Li, Tong Zhou, Lei Zhang*, Jian Qu, Zhijie Mao, Ximiao Gu, Xin Zhang, Su, Jing*, Ferrocenylseleno-dopamine functionalized carbon dots for redox-gated imaging and drug delivery in cancer cells. Dyes and Pigments, 2022, 205, 110586.

(10) Yeqiu Wang, Pengfei Dong, Jing Huang, Hui Xu,* Jianping Lei,* Lei Zhang.* Direct electrochemistry of silver nanoparticles-decorated metal-organic frameworks for telomerase activity sensing via allosteric activation of an aptamer hairpin, Analytica Chimica Acta, 2021, 1184, 339036.

(11) Huimin Xu, Yaqin Sang, Bin Xu, Li Zhang, Lei Zhang,* Hui Xu,* Immobilization of gold nanoparticles on poly(4-vinylpyridine)-grafted carbon nanotubes as heterogeneous catalysts for hydrogenation of 4-Nitrophenol, ACS Applied Nano Materials 2020, 3, 12169−12177.

(12) Michael Isselstein, ^# Lei Zhang, ^# Viktorija Glembockyte, Oliver Brix, Gonzalo Cosa, Philip Tinnefeld, Thorben Cordes.* Self-healing dyes—keeping the promise? The Journal of Physical Chemistry Letters 2020, 11, 4462−4480. (^# equal contribution)

(13) Xianjiu Liao,^# Lei Zhang^#, Sina Wang, Jianping Lei.* Stepwise electrocatalytic reduction of nitric oxide by cationic picket-fence porphyrin in an ultrathin phospholipid film. Electrochemistry Communications, 2019, 100, 60−63. (^# equal contribution)

(14) Lei Zhang, Jun Zhou, Fengjiao Ma, Hui Xu, Huangxin Ju,* Jianping Lei.* Single-Sided Competitive Axial Coordination of G-Quadruplex/Hemin as Molecular Switch for Imaging Intracellular Nitric Oxide. Chemistry - A European Journal 2019, 25, 490−494.

(15) Fengjiao Ma,^# Lei Zhang,^# B. J. C. Wong, Jianping Lei.* In Situ Simultaneous Profiling of Phosphorylation and Ubiquitination by Single Excitation-Duplexed Luminescence Resonance Energy Transfer. Chemical Communication 2018, 54, 3648–3651. (^# equal)

(16) Lei Zhang, Jianping Lei,* Fengjiao Ma, Pinghua Ling, Jintong Liu, Huangxian Ju.* A Porphyrin Photosensitized Metal−Organic Framework for Cancer Cell Apoptosis and Caspase Responsive Theranostics. Chemical Communication 2015, 51, 10831–10834.

(17) Lei Zhang, Yan Cheng, Jianping Lei,* Yuting Liu, Qing Hao, Huangxian Ju. Stepwise Chemical Reaction Strategy for Highly Sensitive Electrochemiluminescent Detection of Dopamine. Analytical Chemistry 2013, 85, 8001−8007.

(18) Lei Zhang, Jianping Lei,* Lin Liu, Changfeng Li, Huangxian Ju. Self-Assembled DNA Hydrogel as Switchable Material for Aptamer-Based Fluorescent Detection of Protein. Analytical Chemistry 2013, 85, 11077–11082.