褚雪强
南京工业大学
Email: xueqiangchu@163.com; xueqiangchu@njtech.edu.cn
ORCID: 0000-0002-9173-1508; Researcher ID: T-3254-2018
主页：http://chem.njtech.edu.cn/info/1073/3152.htm
课题组网站：https://www.x-mol.com/groups/shen_zhiliang/people/32605
课题组每年招收硕士研究生3-6名欢迎报考!
教育、工作经历：
(5) 2022.12-，麦吉尔大学，博士后（CSC）（合作导师：Chao-Jun Li教授）
(4) 2019.01-，南京工业大学，化学与分子工程学院（IAS），讲师、副教授（合作者：沈志良教授）
(3) 2017.07-2018.12，南京工业大学，先进化学制造研究院，助理教授（合作者：沈志良教授和Teck-Peng Loh教授）
(2) 2012.09-2017.06，苏州大学，博士（导师：纪顺俊教授和徐小平教授）
(1) 2008.09-2012.06，苏州大学，学士（导师：纪顺俊教授和徐小平教授）
研究方向：
多重C-F键官能化、含氟杂环化合物合成、绿色化学
研究小结：
在多重C-F键官能化反应研究方面，取得了具有重要影响力的原创性研究成果。先后在国内外有影响的学术刊物，如Chemical Reviews, Chem, ACS Catalysis, Green Chemistry, Organic Letters, iScience等上公开发表论文近百篇，其中以第一作者或通讯作者身份公开发表>50篇论文，包含ESI热点论文1篇，ESI高被引论文3篇，一篇入选2022 Green Chemistry Hot Articles论文，一篇论文曾被ACS Catalysis主编选为ACS Editors' Choice，H-index 19，多篇论文被Frontiers Journals、Organic Chemistry Portal、X-MOL，CBG，化学加等作为亮点进行报道和评述。参与撰写书章节1章，已申请或授权的专利十多项。目前为Journal of the American Chemical Society, Angewandte Chemie International Edition, Organic Letters, Chemical Communication, Chemistry - A European Journal, The Journal of Organic Chemistry等期刊特邀审稿人。
科研项目：
国家自然科学基金项目（22001121），24万，负责人，在研;
江苏省自然科学基金项目（BK20180690），20万，负责人，结题;
南京工业大学科研启动经费（39837146），20万，负责人，在研;
国家自然科学基金项目（21772138），64万，骨干，结题;
所获荣誉：
教育部国家奖学金三次（2011 & 2015 & 2016）;
苏州大学各类奖学金（2010-2017）;
教育部《中国研究生》杂志123期封面人物;
“德国林岛诺贝尔获得者大会”评选活动，苏州大学代表（2017）;
苏州“四创”好青年候选人;
苏州大学优秀博士论文（2017）;
苏州大学优秀博士毕业生（2017）;
国家留学基金委资助（2019）;
南京工业大学优秀本科论文指导教师（2020 & 2022）;
南京工业大学化学与分子工程学院教育教学贡献奖（2021）;
南京工业大学化学与分子工程学院科学研究贡献奖（2021）;
南京工业大学化学与分子工程学院青年教师授课竞赛二等奖（2022）;
南京工业大学微课竞赛二等奖（2022）;
教学信息：
主讲《有机化学
指导本科生（张要威、李琳、刘丽丽）获第十四届本科生学术科技论坛三等奖;
指导本科生（郭一聪）获得2020届校优秀本科毕业论文;
指导本科生（郭一聪）获得2020届江苏省优秀本科毕业论文三等奖;
指导研究生（谢婷）获得2020届校优秀硕士毕业论文;
指导本科生（罗鑫龙、唐茜）主持国家级大学生创新创业训练计划项目(202110291019Z)和校级项目多项;
协助指导研究生获国家奖学金（2019员金金、2020程步清、2021宋轩笛、2022张斯旋）;
指导研究生（孙莉雯）获2022年化学与分子工程学院“长青杯”研究生科技论坛暨校第二十指导四届研究生科技论坛分论坛一等奖;
指导研究生（孙莉雯）获2022南京工业大学第二十四届科技论坛校二等奖;
指导本科生（王明铭）获得2022届校优秀本科毕业论文;
研究成果（仅列通讯或第一作者论文）：
54. X.-Q. Chu,* L.-W. Sun, J.-Wei Chen, Y.-L. Chen, M.-Q. Zhu, J. Zhou,* M. Ma, Z.-L. Shen,* “On-Water” Defluorophosphorylation of Trifluoromethylated Enones with Phosphine Oxides, 2022, Submitted.
53. Z.-L. Yu,# J.-W. Chen,# Y.-L. Chen, R.-J. Zheng, M. Ma, J.-P. Chen,* Z.-L. Shen,* X.-Q. Chu,* DMSO-Promoted Difluoroalkylation of Organophosphonium Salts with Difluoroenol Silyl Ethers, Org. Lett. 2022, 24, 5557–5561. (IF 2022 = 6.072, #Equal contribution, highlighted by CBG)
52. Y.-L. Chen, L.-W. Sun, J.-W. Chen, M.-Q. Zhu, M. Ma, Z.-L. Shen,* X.-Q. Chu,* Four-Component Defluorinative Reaction of Allylic Fluorides, Amidines, and Cs2CO3 under Transition-Metal-Free Conditions, Green Chem. 2022, DOI: 10.1039/D2GC02045A. (IF 2022 = 11.034)
51. W.-X. Li, B.-W. Yang, X. Ying, X.-Q. Chu,* X. Zhou,* M. Ma, Z.-L. Shen,* Nickel-Catalyzed Direct Cross-Coupling of Diaryl Sulfoxide with Aryl Bromide, J. Org. Chem. 2022, DOI: 10.1021/acs.joc.2c01513.
50. X.-Q. Chu,* S.-Z. Cai, Z.-L. Yu, J.-W. Chen, M. Ma, Patrick J. Walsh,* Z.-L. Shen,* Defluorophosphorylation of Fluoroalkyl Peroxides for the Synthesis of Organophosphorus Heteroarenes, 2022, Submitted.
49. X.-Q. Chu,* Y.-L. Chen,# J.-W. Chen,# Z.-L. Yu, D. Ge, M. Ma, Z. Shi,* Z.-L. Shen,* Recent Advances in Transition-Metal-Catalyzed Enantioselective Defluorinative Reactions, 2022, Submitted. (Review, #Equal contribution)
48. M.-M. Guo,# Z.-L. Yu,# Y.-L. Chen, D. Ge,* M. Ma, Z.-L. Shen, X.-Q. Chu,* Difluorinated Silyl Enol Ethers as Fluorine-Containing Building Blocks for the Synthesis of Organofluorine Compounds, Chin. J. Org. Chem. 2022, DOI: 10.6023/cjoc202204060. (In Chinese, Review)
47. Q.-D. Wang,* S.-X. Zhang, Z.-W. Zhang, Y. Wang, M. Ma, X.-Q. Chu,* Z.-L. Shen,* Palladium-Catalyzed Sonogashira Coupling of Heterocyclic Phosphonium Salt with Terminal Alkyne, Org. Lett. 2022, 24, 4919–4924. (IF 2022 = 6.072)
46. X.-Q. Chu,* L.-W. Sun, Y.-L. Chen, J.-W. Chen, Z.-L. Shen,* HP(O)Ph2/H2O-Promoted Hydrodefluorination of Trifluoromethyl Alkenes, Green Chem. 2022, 24, 2777–2782. (IF 2022 = 11.034, 2022 Green Chemistry Hot Articles, highlighted by CBG)
45. D. Ge, Zhenhua Jia, X.-Q. Chu,* TMSCF2Br as Both a C1 Synthon and a F1 Reagent, Green Synth. Cat. 2022, DOI: 10.1016/j.gresc.2022.02.001. (Invited Highlight)
44. M.-M. Guo,# X.-D. Song,# X. Liu, Y.-W. Zheng, X.-Q. Chu,* W. Rao, Z.-L. Shen,* Iron(III)-Catalyzed Difluoroalkylation of Aryl Alkyne with Difluoroenol Silyl Ether in the Presence of Trimethylsilyl Chloride, Adv. Synth. Catal. 2022, 364, 2454–2460. (IF 2022 = 5.981, #Equal contribution)
43. D. Ge, J.-W. Chen, Pei Xu,* Jinyin Pan, X.-Q. Chu,* 1,n-Thiosulfonylation Using Thiosulfonates as Dual Functional Reagents. Chin. Chem. Lett. 2022, 33, 4732–4739. (IF 2020 = 8.455, Review)
42. W.-X. Li, B.-W. Yang, J.-H. Na, W.-D. Rao, X.-Q. Chu,* Z.-L. Shen,* Palladium-Catalyzed Cross-Coupling of Alkylindium Reagent with Diaryliodonium Salt, Tetrahedron Lett. 2022, 95, 153729. (IF 2022 = 2.032)
41. D. Ge, X.-Q. Chu,* Multiple-Fold C-F Bond Functionalization for the Synthesis of (Hetero)cyclic Compounds: Fluorine as a Detachable Chemical Handle. Org. Chem. Front. 2022, 9, 2013–2055. (IF 2022 = 5.456, Review)
40. Y.-Y. Cui, J.-H. Na, M.-M. Guo, J.-Y. Huang, X.-Q. Chu,* W. Rao, Z.-L. Shen,* Cobalt-Catalyzed Cross-Coupling of Heterocyclic Phosphonium Salts with Arylmagnesium Reagents, Tetrahedron Lett. 2022, 92, 153662. (IF 2022 = 2.032)
39. L.-W. Sun, Z.-L. Yu, X.-L. Luo, M. Ma, Z.-L. Shen,* X.-Q. Chu,* Transition-Metal-Free Hydroamination/Defluorination/Cyclization of Perfluoroalkyl Alkynes with Amidines. Org. Chem. Front. 2022, 9, 109–116. (IF 2022 = 5.456, Featured in Frontiers Journals)
38. S.-X. Zhang,# X.-R. Li,# W.-X. Li, W.-D. Rao, D. Ge,* Z.-L. Shen, X.-Q. Chu,* Iron(0)-mediated Henry-type Reaction of Bromonitromethane with Aldehydes for the Efficient Synthesis of 2-Nitro-alkan-1-ols. Chin. J. Org. Chem. 2022, 42, 235-241.
37. X.-Q. Chu,* D. Ge, Y.-Y. Cui, Z.-L. Shen,* C.-J. Li.* Desulfonylation via Radical Process: Recent Developments in Synthetic Applications. Chem. Rev. 2021, 121, 12548–12680. (IF 2021 = 60.622, Invited Review, ESI Hot Article, ESI Highly Cited Paper, highlighted by X-MOL)
36. D. Ge, X. Wang, X.-Q. Chu,* SOMOphilic Alkynylation Using Acetylenic Sulfones as Functional Reagents. Org. Chem. Front. 2021, 8, 5145–5164. (IF 2021 = 5.281, Review)
35. Q.-D. Wang,* Y.-W. Wang, T. Xie, Y.-Y. Cui, M. Ma, Z.-L. Shen, X.-Q. Chu,* Three-Component Bisannulation for the Synthesis of Trifluoromethylated Tetracyclic Aza-Aromatics through Six C(sp3)-F Bond Cleavage and Four C-N Bond Formation. J. Org. Chem. 2021, 86, 8236–8247. (IF 2021 = 4.354)
34. S.-Z. Cai,# D. Ge,# L.-W. Sun, W. Rao, X. Wang, Z.-L. Shen,* X.-Q. Chu,* Three-Component Heteroannulation for Tetrasubstituted Furan Construction Enabled by Successive Defluorination and Dual Sulfonylation Relay. Green Chem. 2021, 23, 935–941. (IF 2021 = 10.182, ESI Highly Cited Paper, #Equal Contribution)
33. X.-L. Luo,# D. Ge,# Z.-L. Yu, X.-Q. Chu,* P. Xu,* Vitamin B1-Catalyzed Aerobic Oxidative Esterification of Aromatic Aldehydes with Alcohols. RSC Adv. 2021, 11, 30937–30942. (IF 2021 = )
32. D. Ge, X.-Q. Chu,* Stepwise C(sp3)-F Bond Functionalizations of Trifluoroacetic Acid Derivatives. Chin. J. Org. Chem. 2021, 41, 2150–2151. (In Chinese, Invited Highlight)
31. D. Ge, X. Wang, X.-Q. Chu,* Difluoroalkylation/1,2-Aryl Migration of Allylic Alcohols Under Transition Metal-Free Conditions. Tetrahedron Lett. 2021, 70, 153002. (IF 2021 = 2.415)
30. D. Ge, X.-L. Luo, X. Tang, C.-B. Pang, X. Wang, X.-Q. Chu,* Metal-Free [3 + 2 + 1] Annulation of Allylic Alcohols, Ketones, and Ammonium Acetate: Radical-Involving Synthesis of 2,3-Diarylpyridine Derivatives. Org. Biomol. Chem. 2021, 19, 2277–2283. (Featured in Org. Chem. Highlights: Heteroaromatics)
29. Q.-D. Wang,* C. Zhang, L.-W. Sun, X.-L. Luo, W. Rao, Z.-L. Shen, X.-Q. Chu,* Defluorinative Phosphorylation of Perfluoroalkyl Ketones: Synthesis of Fluoroalkylated and Phosphorylated Furan Derivatives. Org. Chem. Front. 2021, 8, 1503–1509. (IF 2021 = 5.281, Featured in Frontiers Journals)
28. B.-Q. Cheng, D. Ge,* X. Wang, X.-Q. Chu,* Perfluoroalkyl Halides as Fluorine-Containing Building Blocks for the Synthesis of Fluoroalkylated Heterocycles. Chin. J. Org. Chem. 2021, 41, 1925–1938. (In Chinese, Review)
27. X.-Q. Chu,* M.-L. Zhi, S.-X. Zhang, Y.-W. Wang, W. Rao, H. Xu, Z.-L. Shen,* Palladium-Catalyzed Defluorinative Alkynylation of Polyfluoroalkyl Ketones with Alkynes for the Synthesis of Fluorinated Fused Furans. Org. Chem. Front. 2021, 8, 572–578. (IF 2021 = 5.281)
26. D. Ge, M.-L. Wang, X. Wang, X.-Q. Chu,* Iron-Catalyzed C-O Bond Functionalization of Butyrolactam Derivatives with Various N-/C-Nucleophiles. New J. Chem. 2020, 44, 21064–21069.
25. T. Xie, C. Zhang, S.-X. Zhang, W. Rao, H.-Y. Xu, Z.-L. Shen,* X.-Q. Chu,* Synthesis of Polycyclic Furan and Chromene Derivatives via Cascade Reactions Enabled by Cleavage of Multiple C(sp3)-F Bonds. Adv. Synth. Catal. 2020, 362, 4736–4743.
24. X.-Q. Chu,* T. Xie, Y.-W. Wang, X.-R. Li, W. Rao, H. Xu, Z.-L. Shen,* Synthesis of Di(hetero)aryl Sulfides by Defluorinative Sulfenylation of Polyfluoroalkyl Ketones with Sodium Sulfinates or Arylsulfonyl Chlorides. Chem. Commun. 2020, 56, 8699–8702.
23. T. Xie,# G.-Q. Wang,# Y.-W. Wang, W. Rao, H. Xu, S. Li,* Z.-L. Shen,* X.-Q. Chu,* Selective Quadruple C(sp3)-F Functionalization of Polyfluoroalkyl Ketones. iScience 2020, 23, 101259.
22. S.-W. Zhao, S.-Z. Cai, M.-L. Wang, W. Rao, H. Xu, L. Zhang, X.-Q. Chu,* Z.-L. Shen,* Selective C(sp3)-H Functionalization of Alkyl Esters with N-/S-/O-Nucleophiles Using Perfluoroalkyl Iodide as Oxidant. Adv. Synth. Catal. 2020, 362, 3388–3394.
21. X.-Q. Chu, D. Ge, M.-L. Wang, W. Rao, T.-P. Loh,* Z.-L. Shen,* Chemo- and Regioselective Ring Construction Driven by Visible-Light Photoredox Catalysis: An Access to Fluoroalkylated Oxazolidines Featuring an All-Substituted Carbon Stereocenter. Adv. Synth. Catal. 2019, 361, 4082–4090.
20. X.-Q. Chu, Z.-L. Shen,* T.-P. Loh,* Regioselective (Hetero)aryl C-H Thianthrenation and Late-Stage Transformations. Chem 2019, 5, 1025–1027. (Preview).
19. X.-Q. Chu, D. Ge, T.-P. Loh,* Z.-L. Shen,* Oxidant-Directed Chemoselective Sulfonylation and Sulfonyloximation of Alkenes via Cleaving C-S Bond in TosMIC. Org. Chem. Front. 2019, 6, 835–840. (IF 2020 = 5.281)
18. X.-Q. Chu, D. Ge, Z.-L. Shen,* T.-P. Loh,* Recent Advances in Radical-Initiated C(sp3)-H Bond Oxidative Functionalization of Alkyl Nitriles. ACS Catal. 2018, 8, 258−271 (Review, ACS Editors' Choice, ESI Highly Cited Paper).
17. T. Xie, Y.-W. Zhang, L.-L. Liu, Z.-L. Shen, T.-P. Loh,* X.-Q. Chu.* Polycyclic Heteroaromatic Ring Construction Driven by Silver/Cobalt Co-Catalyzed Desulfonylative and Defluorinative Fragment-Recombination of Enol Nonaflates with Amidines. Chem. Commun. 2018, 54, 12722−12725.
16. X.-Q. Chu, T. Xie, L. Li, D. Ge, Z.-L. Shen,* T.-P. Loh,* Combining Fluoroalkylation and Defluorination to Enable Formal [3 + 2 + 1] Heteroannulation by Using Visible-Light Photoredox Organocatalysis. Org. Lett. 2018, 20, 2749–2752.
15. X.-Q. Chu, B.-Q. Cheng, Y.-W. Zhang, D. Ge, Z.-L. Shen,* T.-P. Loh,* Copper-Catalyzed Three-Component Cyclization of Amidines, Styrenes, and Fluoroalkyl Halides for the Synthesis of Modular Fluoroalkylated Pyrimidines. Chem. Commun. 2018, 54, 2615–2618 (highlighted by X-MOL).
2013-2017 @Soochow University
14. X.-Q. Chu, W.-B. Cao, X.-P. Xu,* S.-J. Ji,* Iron Catalysis for Modular Pyrimidine Synthesis through β-Ammoniation/Cyclization of Saturated Carbonyl Compounds with Amidines. J. Org. Chem. 2017, 82, 1145–1154.
13. X.-Q. Chu, X.-P. Xu,* S.-J. Ji,* TBAI-Catalyzed/Water-Assisted Double C−S Bond Formations: An Efficient Approach to Sulfides via Metal-Free Three-Component Reactions. Chem. Eur.–J. 2016, 22, 14181–14185.
12. X.-Q. Chu, D. Liu, Z.-H. Xing, X.-P. Xu,* S.-J. Ji,* Palladium-Catalyzed Cyclization of Alkenes with Organohalides. Org. Lett. 2016, 18, 776–779.
11. X.-Q. Chu, Z.-H. Xing, H. Meng, X.-P. Xu,* S.-J. Ji,* Copper-Mediated Radical Alkylarylation of Unactivated Alkenes with Acetonitrile Leading to Fluorenes and Pyrroloindoles. Org. Chem. Front. 2016, 3, 165–169.
10. X.-Q. Chu, H. Meng, Y. Zi, X.-P. Xu,* S.-J. Ji,* Oxidative C(sp3)-H Functionalization of Acetonitrile and Alkanes with Allylic Alcohols under Metal-Free Conditions. Org. Chem. Front. 2015, 2, 216–220.
9. X.-Q. Chu, X.-P. Xu,* H. Meng, S.-J. Ji,* Synthesis of Functionalized Benzoxazines by Copper-Catalyzed C(sp3)–H Bond Functionalization of Acetonitrile with Olefinic Amides. RSC Adv. 2015, 5, 67829–67832.
8. X.-Q. Chu, H. Meng, X.-P. Xu,* S.-J. Ji,* One-Pot Synthesis of Allylic Sulfones, Ketosulfones, and Triflyl Allylic Alcohols from Domino Reactions of Allylic Alcohols with Sulfinic Acid under Metal-Free Conditions. Chem. Eur.–J. 2015, 21, 11359–11368 (Front Cover & Hot Paper).
7. X.-Q. Chu, H. Meng, Y. Zi, X.-P. Xu,* S.-J. Ji,* Metal-Free Oxidative Radical Addition of Carbonyl Compounds to a, a-Diaryl Allylic Alcohols: Synthesis of Highly Functionalized Ketones. Chem. Eur.–J. 2014, 20, 17198–17206.
6. X.-Q. Chu, Y. Zi, H. Meng, X.-P. Xu,* S.-J. Ji,* Synthesis of 1,4-Dihydroquinoline Derivatives under Transition-Metal-Free Conditions and Their Diverse Applications. Org. Biomol. Chem. 2014, 12, 4243–4251.
5. X.-Q. Chu, H. Meng, Y. Zi, X.-P. Xu,* S.-J. Ji,* Metal-Free Oxidative Direct C(sp3)–H Bond Functionalization of Ethers with a, a-Diaryl Allylic Alcohols. Chem. Commun. 2014, 50, 9718–9721.
4. X.-Q. Chu, Y. Zi, H. Meng, X.-P. Xu,* S.-J. Ji,* Radical Phosphinylation of a, a-Diaryl Allylic Alcohols with Concomitant 1,2-Aryl Migration. Chem. Commun. 2014, 50, 7642–7645.
3. X.-Q. Chu, Y. Zi, X.-M. Lu, S.-Y. Wang,* S.-J. Ji,* Intramolecular Pd-Catalyzed C-H Functionalization: Construction of Fused Tetracyclic Bis-Indole Alkaloid Analogues. Tetrahedron 2014, 70, 232–238.
2. X.-Q. Chu, S.-Y. Wang,* S.-J. Ji,* Recyclable NaHSO4 Catalyzed Alkylation of Tertenamides with Indoles or Amines in Water: Facile Construction of Pharmaceutically Analogous Bis-Alkaloid Scaffolds. RSC Adv. 2013, 3, 8380–8387.
1. X.-Q. Chu, R. Jiang, Y. Fang, Z.-Y. Gu, H. Meng, S.-Y. Wang,* S.-J. Ji,* Acidic-Functionalized Ionic Liquid as an Efficient, Green, and Metal-Free Catalyst for Benzylation of Sulfur, Nitrogen, and Carbon Nucleophiles to Benzylic Alcohols. Tetrahedron 2013, 69, 1166–1174.
Book
1. S.-Y. Wang, X.-Q. Chu, Y. Fang, S.-J. Ji, Acetonitrile as Reagents in Organic Synthesis: Reactions and Applications, Solvents as Reagents in Organic Synthesis 2018,355-375.
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