Practical allylation with unactivated allylic alcohols under mild conditions

Shuangshuang Li^a, Ju Qiu^a, Bowen Li^a, Zuolian Sun^a, Peizhong Xie^a*, and Teck-Peng Loh^ab*

^a School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, P. R. China.

b Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371.

Abstract: A practical palladium/calcium catalytic system was developed for dehydrative allylation concerning unactivated allylic alcohols. EtOH solvent with H₂O additive was identified as powerful media to accelerate proton transfer. That catalytic system and environmentally benign media enabled a variety of soft carbonic nucleophiles and allylic alcohols reacted smoothly at room temperature with water as the only byproduct. A wide-spectrum of allylic compounds bearing a variety of functional groups can be obtained with high to excellent yields.

Org. Chem. Front. 2021, 8, 3354-3359.（影响因子：5.281）

论文链接：https://pubs.rsc.org/en/content/articlepdf/2021/qo/d1qo00490e