Nickel-catalyzed direct cross-coupling of heterocyclic phosphonium salt with aryl bromide

Yan-Ying Cui,^a Wen-Xin Li,^a Na-Na Ma,^a Chuanji Shen,^b Xiaocong Zhou,*^b Xue-Qiang Chu,^a Weidong Rao,^c and Zhi-Liang Shen*^a

^a Technical Institute of Fluorochemistry (TIF), Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, China.

^b College of Biological, Chemical Science and Engineering, Jiaxing University, 118 Jiahang Road, Jiaxing 314001, China.

^c Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-Forest Biomass, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China

Abstract: The direct cross-couplings of heterocyclic phosphonium salts with aryl bromides could be successfully realized by performing the reactions in THF at ambient temperature with the aid of nickel(II) catalyst, 1,10-phenanthroline-5,6-dione ligand, magnesium turnings, and lithium chloride, providing an easy entry to 4-arylated pyridine, quinoline, quinoxaline, and pyrazine.

Org. Chem. Front. 2021, 8, 6931-6936. (Impact factor: 5.281)

论文链接：https://pubs.rsc.org/en/Content/ArticleLanding/2021/QO/D1QO01474A