Reductive-Delay Heck 1,1-Diarylation of Terminal Alkenes

Huihui Shao,^† Yao Zhao,^† Shuangqiang Wang,^‡ Rizhi Chen,^‡ Jianrong Steve Zhou,^§ and Xiaojin Wu^†*

^† Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, China

^‡ State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing 211816, China

^§ State Key Laboratory of Chemical Oncogenomics, Guangdong Provincial Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China

Abstract: Pd-catalyzed chemo- and regiocontrollable 1,1-diarylation of unactivated aliphatic alkenes with two aryl halides was developed. Under the cationic reductive-delay Heck pathway, the first aryl insertion is followed by β-H elimination, while the second aryl insertion is terminated by C−H bond formation.

Org. Lett. 2022. DOI: 10.1021/acs.orglett.2c02416. (Impact factor: 6.072)

论文链接: https://doi.org/10.1021/acs.orglett.2c02416