Cu(I)-Catalyzed Oxytrifluoromethylation of N-Boc-Ynamides for the Construction of Trifluoromethylated Oxazolones

Yue Zuo, Xingyuan Ye, Dongjie Jiang, Shuai Zhou, Mengyuan Yu, and Guangke He^a*

Abstract: A highly chemo-selective copper(I)-catalyzed oxytrifluoromethylation of N-Boc-ynamides with TMSCF₃ has been achieved, affording the trifluoromethylated oxazolones in 51-99% yields. The reaction proceeds at room temperature and tolerates a variety of functional groups such as –X, –OMe, alkenyl, and other substituents. And the resulting oxazolones provide easy access to α-CF₃-substituted amines through decarboxylative reduction.

Adv. Synth. Catal., 2022, 364, 4146-4151.

论文链接：https://doi.org/10.1002/adsc.202200971。