Liberate Glycosylation from Protecting Groups 

无保护基糖基化反应开发

时间：2024年11月25日 9:30-10:30

地点：化学学科楼A508

报告人简介：

钮大文，博士，四川大学教授。长期致力于从事糖类合成与功能研究，为克服糖类合成中长期面临的选择性控制难题建立了系列方案，实现了对复杂生物分子直接无保护基糖基化，开发了可用于蛋白质直接选择性糖基化的化学方法，并将之应用于抗体偶联药物开发中。迄今在Science, Nature, Nature Chem., Nature Catal.,Nature Synth., JACS, Angew., Acc. Chem. Res.等权威期刊上发表研究论文30余篇。国家杰出青年科学基金获得者，入选中组部“海外高层次人才”、四川省学术与技术带头人。获得霍英东青年教师基金 (2019)，惠永正糖科学奖(2023)，中国化学会青年化学奖(2021)，中国化学会糖化学青年学者奖(2023)等多个学术奖励。

报告摘要：

Glycosylation methods initiated by non-ionic processes have significant, but underexplored potential. In order to better exploit the power the such glycosylation methods, we have developed a range of bench stable glycosyl donors that can be readily prepared from simple starting materials. These donors can be activated to form glycosyl radicals or glycosyl transition metal complexes under mild conditions. Enabled by the use of these donors, we have developed a series of glycosylation methods and accomplished synthesis of diverse glycoconjugates that were previously difficult to access. In many cases, no protecting group on glycosyl donors is required. Moreover, it allows the utilization of external, delicate reagents or catalysts to control stereoselectivity, which is another essential task in carbohydrate synthesis.